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Obesity is one of the most common health concerns todayHerbal-based food supplements are widely used to treat obesityAmong themthe African cactiform Hoodia gordonii supplements are extremely popularThe development of Hoodia and P57the purported active ingredienthas been problematic due to controversy about intellectual property rights and limited natural resourcesTo datethe true active components and molecular targets of Hoodia remain unclearHerewe demonstrate that Gordonoside Fa compound from Hoodiaactivates GPR119a receptor critically involved in metabolic homeostasisand leads to increased insulin secretion and reduced food intakeThe successful synthesis of Gordonoside F described here will provide an opportunity for developing new drugs in treating metabolic diseases.

In realitythe Bushmen’s trim physique is a result of wandering around the desert in the hot sun for tens of miles each day looking for foodThe combination of extreme caloric exertion and a scarcity of food tends to result in a lack of obesitywith or without hoodia.

Putative active principlea steroidal glycoside termed P57appears to act at the hypothalamic level to shut off hunger signals.

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