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Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administrationwhenever solution and container permitDo not use cyclophosphamide vials if there are signs of meltingMelted cyclophosphamide is a clear or yellowish viscous liquid usually found as a connected phase or in droplets in the affected vials.
Sometimesmesna is used concomitantly as prophylaxis against hemorrhagic cystitis.
Add the diluent to the vial and shake it vigorously to dissolveIf the powder fails to dissolve immediately and completelyit is advisable to allow the vial to stand for a few minutesUse the quantity of diluent shown below to constitute the product:
Cyclophosphamide can cause fetal harm when administered to a pregnant woman and such abnormalities have been reported following cyclophosphamide therapy in pregnant womenAbnormalities were found in two infants and a six-month-old fetus born to women treated with cyclophosphamideEctrodactylia was found in two of the three casesNormal infants have also been born to women treated with cyclophosphamide during pregnancyincluding the first trimesterIf this drug is used during pregnancyor if the patient becomes pregnant while takingreceivingthis drugthe patient should be apprised of the potential hazard to the fetusWomen of childbearing potential should be advised to avoid becoming pregnant.
Nervous Systemencephalopathyconvulsiondizzinessneurotoxicity has been reported and manifested as reversible posterior leukoencephalopathy syndromemyelopathyperipheral neuropathypolyneuropathyneuralgiadysesthesiahypoesthesiaparesthesiatremordysgeusiahypogeusiaparosmia.
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