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The triamterene and hydrochlorothiazide components of MAXZIDE and MAXZIDE-25 MG are well absorbed and are bioequivalent to liquid preparations of the individual components administered orallyFood does not influence the absorption of triamterene or hydrochlorothiazide from MAXZIDE or MAXZIDE-25 MG tabletsThe hydrochlorothiazide component of MAXZIDE is bioequivalent to single entity hydrochlorothiazide tablet formulations.

Dispense in a tightlight-resistant container as defined in the USP using a child-resistant closure.

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The development of hyperkalemia associated with potassium-sparing diuretics is accentuated in the presence of renal impairmentsee CONTRAINDICATIONSPatients with mild renal functional impairment should not receive this drug without frequent and continuing monitoring of serum electrolytesCumulative drug effects may be observed in patients with impaired renal functionThe renal clearances of hydrochlorothiazide and the pharmacologically active metabolite of triamterenethe sulfate ester of hydroxytriamterenehave been shown to be reduced and the plasma levels increased following MAXZIDEtriamterene and hydrochlorothiazideadministration to elderly patients and patients with impaired renal function.

Tell your doctor right away if you have any serious side effectsincludingnausea/vomiting that doesn’t stopstomach/abdominal painyellowing eyes/skindark urinesigns of infectionsuch as sore throat that doesn’t go awayfeverchillscoughsigns of kidney problemssuch as pain in the side/back/abdomenpainful urinationblood in the urinechange in the amount of urinejoint painsuch as big toe paineasy bruising/bleeding.

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may administer hydrochlorothiazide; triamterene without regard to meals.

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