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Pharmacodynamics of LIORESAL INTRATHECAL Intrathecal BolusAdult PatientsThe onset of action is generally one-half hour to one hour after an intrathecal bolusPeak spasmolytic effect is seen at approximately four hours after dosing and effects may last four to eight hoursOnsetpeak responseand duration of action may vary with individual patients depending on the dose and severity of symptoms.

An attempt should be made to discontinue concomitant oral antispasticity medication to avoid possible overdose or adverse drug interactionseither prior to screening or following implant and initiation of chronic LIORESAL INTRATHECAL infusionReduction and discontinuation of oral anti-spasmotics should be done slowly and with careful monitoring by the physicianAbrupt reduction or discontinuation of concomitant antispastics should be avoided.

Use this medication regularly to get the most benefit from itTo help you remembertake it at the same times each dayDo not stop taking this medication without consulting your doctorSome conditions may become worse when this drug is suddenly stoppedAlsoyou may experience withdrawal symptoms such as hallucinations and seizuresTo prevent withdrawal reactionsyour doctor may reduce your dose graduallyConsult your doctor or pharmacist for more detailsand report any withdrawal reactions right away.

It is mandatory that the patientall patient caregiversand the physicians responsible for the patient receive adequate information regarding the risks of this mode of treatmentAll medical personnel and caregivers should be instructed in 1the signs and symptoms of overdose2procedures to be followed in the event of overdose and 3proper home care of the pump and insertion site.

The lowest dose compatible with an optimal response is recommendedIf benefits are not evident after a reasonable trial periodpatients should be slowly withdrawn from the drugsee WARNINGS Abrupt Drug Withdrawal

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lioresal was approved for use in the treatment of alcoholism.

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