Paroxetine, fluoxetine, and sertraline are similar in effectiveness for major depression and depression with high levels of anxiety 3,5.

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PediatricSafety and efficacy not established GeriatricCaution should be used in the elderly because paroxetine is the most sedating and anticholinergic of the selective serotonin reuptake inhibitors The elderly are prone to SSRI/SNRI-induced hyponatremiamonitor closely.

Paroxetine may also be used for purposes not listed in this medication guide.

Do not use an MAO inhibitor within 14 days before or 14 days after you take paroxetineA dangerous drug interaction could occurMAO inhibitors include isocarboxazidlinezolidphenelzinerasagilineselegilineand tranylcypromineAfter you stop taking paroxetine you must wait at least 14 days before you start taking an MAO inhibitor.

Ask your doctor before taking a nonsteroidal anti-inflammatory drugNSAIDfor painarthritisfeveror swellingThis includes aspirinibuprofenAdvilMotrinnaproxenAlevecelecoxibCelebrexdiclofenacindomethacinmeloxicamand othersUsing an NSAID with paroxetine may cause you to bruise or bleed easily.

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