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Serious gastrointestinal adverse effects such as bleedingulceration and perforationwhich can be fatalhas been reported and can occur at any time with or without warning symptoms in patients treated with NSAIDs or a previous history of serious GI eventsIf any sign of gastrointestinal bleeding occursLodine should be stopped immediately.
DermatologicalBullous reactions including Stevens Johnson Syndrome and Toxic Epidermal Necrolysisvery rarePhotosensitivity.
Etodolac is a member of the pyranocarboxylic acid class of NSAIDsIn vitro data suggest that etodolac is not COX-2 selective in dogsHowever in vivo data are conflictingwith evidence suggesting that platelet thromboxane and gastric prostaglandin PGE 1 were not inhibited by etodolac in dogs at recommended therapeutic dosesThus it is difficult to definitively state whether or not etodolac is COX-1 sparing in vivoEtodolac is approved as an oral formulation for use in managing pain and inflammation associated with canine OAClinically it has been shown to improve rear limb function in dogs with chronic OAAdverse events are primarily seen in the GI tracthoweverkeratoconjunctivitis sicca has also been associated with etodolac administration.
Frequency not reportedSerum creatinine increasedinfectionweight abnormalirritabilitydeafnessmeningitisvertigosepsisdeathweaknessaseptic meningitis.
Frequency not reportedHypertensioncongestive heart failureflushingpalpitationsarrhythmiamyocardial infarctiontachycardiacardiac failure.
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